A General Analysis of Single IP3 Receptors Modulated by Cytosolic Ca2+ and IP3

摘要：

In this report, we remove the constraint of detailed balance and give a general discussion of the modulation of cytosolic Ca2+ and IP3 on the iP3 R channel. By introducing the circulation decomposition theorem in stochastic process, the gating mechanism of single IP3 R is neatly analyzed. Some remarkable differences are found to distinguish between equilibrium and non-equilibrium dynamics. Evidence is given to show that detailed balance is violated to some extent in the IP3R channel. Comparison of surface fittings between equilibrium and non-equilibrium models reveals that the latter model excels evidently. It is emphasized that these interesting phenomena in the non-equilibrium dynamics, present a more comprehensive view of the channel behavior.

作者: Chen Jia Yihan Li Minping Qian

作者单位: School of Mathematical Sciences,Peking University,Beijing 100871,China School of Mathematical Sciences Peking University,Beijing 100871,China Center for Theoretical Biolog

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 89-101

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）