Understanding the Biological Functions of DCF1 Based on Molecular Interaction Network

摘要：

It is important to understand the neural dendrite formation at molecular level. Unfortunately, the regulation mechanisms underlying neural dendrite formation remain unclear. In our previous work, it is found that dentritic cell factors (DCF1) express differentially between undifferentiated and differentiated neural stem cells (NSCs). In this study, we compared whole-genome gene expression data for DCF1-knockout and wild type mice. By integrating gene expression data and protein-protein interaction data, a connected subnetwork that consist of differentially expressed genes is identified. Analyzing the affected subnetwork, we find that glycolysis is enriched for downregulated genes in the extracted subnetwork while biosynthetic process is enriched for up-regulated genes, which give hints that DCF1 is possibly related to these functions and provides guidelines for future experiment verification.

关键词： DCF1 Molecular interaction network Neural dendrite formation

作者: Xing-Ming Zhao Renhong Qian Xiangchun Ju Tieqiao Wen

作者单位: Institute of Systems Biology,Shanghai University,Shanghai 200444,China Institute of Systems Biology,Shanghai University,Shanghai 200444,China The Laboratory of neural mole

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 102-108

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）