A Network-Based Approach for Identifying Effective Drug Combination

摘要：

To cope with complex diseases, combination regimens or combination drugs are increasingly attracting the attention from the area of drug design. However, most of the combination drugs are developed based on clinical experience or by test-and-trial strategy. In this paper, we present a novel network-based systems biology approach to identify effective drug combinations by exploiting high throughput data. As a pilot study, we apply the proposed method to identify combination drug used to treat Type 2 Diabetes. The results on real biological data demonstrate the effectiveness and efficiency of the proposed method.

关键词： Drug combination molecular interaction network active subnetwork gene ezpression

作者: Zikai Wu Luonan Chen

作者单位: Institute of Systems Biology,Shanghai University,Shanghai 200444,China School of Communication and I Institute of Systems Biology,Shanghai University,Shanghai 200444,China Department of Electrical Engi

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 207-213

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）