Mathematical Modeling of Signaling Pathways Leading to Type I IFN Gene Ezpression
Many viruses can escape cellular innate antiviral immune responses by encoding one or more proteins to inhibit the induction of type i interferons (IFN-α/β), which leads to the occurrence of major diseases. However, the mechanisms how some virus-encoded proteins inhibit IFN-α/β induction have not yet been fully understood. Based on available literature and experimental data of classical swine fever virus (CSFV), in this study, we develop a mathematical model of virus- and dsRNA-triggered type 1 IFN signaling pathways, and investigate the quantitative relationship between the dose of the transfected plasmid and the inhibitory effects of Npor Erns. Our simulation results showed that CSFV Npro inhibited both dsRNA- and virus- induced IFN-β expression, and Erns only inhibited exogenous dsRNA triggered IFN-β production, which are agreement with experimental data. The dose-dependent inhibition by Npro or Erns was observed when the transfected plasmid was less than 1.5 μg. Furthermore, when the plasmid was more than 1.5 μg, the inhibitory effects of both Npro and Erns can reach maximum. These results provide insight into systems properties and generation of hypotheses for further research.
Mathematical Model Signaling pathway Type I interferons Virus dsRNA
Xiufen Zou Xueshuang Xiang Yan Chen Zishu Pan
School of Mathematics and Statistics,Wuhan University,Wuhan,430072,China College of Life Sciences,Wuhan University,Wuhan,430072,China
国际会议
The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)
张家界
英文
221-228
2009-09-20（万方平台首次上网日期，不代表论文的发表时间）