Prediction of Differentiation-ralated Pathways Induced by Rho-GDIγ

摘要：

Rho-GDIγ, one of GDP-dissociation inhibitors (GDIs) in the GTPases Rho-subfamily, plays a key role in modulating the activation of GTPases, and contributes to reorganization of actin cytoskeleton, cell aggregation, cell-to-cell adhesion, membrane ruffling, cell motility, and so on. In this work, a functional linkage network that consists of genes differentially expressed between undifferentiated and differentiated neural stem cells (NSCs) is first constructed. Differentiation-ralated pathways induced by Rho-GDIγ are subsequently predicted from the functional linkage network. The results of the biological experiments indicated that overexpression of Rho-GDIγ in neural stem cell line C17.2 upregulates VCP (valosin-containing protein) gene. The results demonstrate that differentiation-related pathways predicted from functional linkage network are indeed reliable.

关键词： Gene ezpression Differentiation-related pathway Functional linkage network

作者: Jiao Wang Xiao Li Tieqiao Wen

作者单位: Institute of Systems Biology,Shanghai University,99 Shangda Road,Shanghai 200444,China Laboratory of molecular neural biology,School of life sciences,Shanghai University,99 Shangda Road,Shanghai 200444,China

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 261-266

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）