Crosstalk of Dysfunctional Pathways in Alzheimers Disease Brains

摘要：

Alzheimers disease (AD) is a major nenrodegenerative disorder leading to dementia in the elderly. We proposed a network-based systems biology approach to detect the dysfunctional crosstalk of pathways in six brain regions of AD disease patients. We identified the relationship between AD pathways and its neighbor pathways to investigate their intersections and relationships. The significance of pathways developed in the fatal disorders and the overlapping strength indicate the impacts of neighbor pathways to AD development. The crosstalk with AD pathways provides evidences for the particular tasks of important neighbor pathways as well as the associations between them.

关键词： Gene ezpression dysfunctional pathway clustering crosstalk Alzheimers disease

作者: Zhi-Ping Liu Luonan Chen

作者单位: Department of Electrical Engineering and Electronics,Osaka Sangyo University,Osaka 574-8530,Japan

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 288-295

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）