Response Time and Its Role in Noise Filtering

摘要：

A cell consists of many interacting biomolecular components that form some basic feed back loops, such as positive or negative feedback loops. When biological signals transduce through cascades consisting of various loops they will be affected or even distorted. Especially, how to process various signals buried in various intrinsiC and extrinsic noises is an important issue. In this paper, a method on how to cope with these signals will be discussed. A parameter to measure the response time of the signal transduction i.e., ι0.9, and its relationship between the response time and noise filtering will be discussed. Generally speaking, the longer the response time is, the better the ability to filter noises will be. Then we discuss how to enhance the ability to filter noises in a positive or negative feedback loops, and draw a conclusion that coupling feedback loops can enhance the ability.

关键词： signal cycle response time noises filtering noises

作者: Dengyu Liu Xiao Chang Ruiqi Wang

作者单位: Institute of Systems Biology,Shanghai University,Shanghai 200444,China College of Physics and athema Institute of Systems Biology,Shanghai University,Shanghai 200444,China

会议类型: 国际会议

会议名称: The 3rd International Symposium on Optimization and System Biology(第三届最优化与系统生物学国际会议 OSB09)

会议地点: 张家界

会议语种:英文

页码: 410-418

在线出版日期: 2009-09-20（万方平台首次上网日期，不代表论文的发表时间）