Application of ultrasonic Irradiation to Control Crystallization

摘要：

The purpose of our study is to propose application of ultrasonic irradiation, and understand ultrasonic primary nucleation phenomena for controlling final product quality via the number of primary nuclei. It was indicated that ultrasonic energy could create a desired crystal size by obtaining suitable nucleation. The effect of ultrasonic irradiation on the control of polymorph in sulfamerazine (SMZ) in acetonitrile at 21℃ was also studied. From the experimental results, the polymorph in SMZ can be controlled with/without ultrasonic irradiation, in order to produce α-form or β-form polymorph. Ultrasonic Irradiation Induced Crystallization, so called sono-crystallization will be applicable by considering the optimum irradiation conditions and solution conditions. And also practical applications are proposed.

关键词： Ultrasonic Irradiation Crystallization Polymorph

作者: Izumi Hirasawa Masahiro Kurotani Etsuko Miyasaka Satomi Ebihara

作者单位: Major in Applied Chemistry, Graduate School of Advanced Science & Engineering Waseda University, 3-4-1 Ohkubo, Shinjyuku, Tokyo, 169-8555 Japan

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 1-14

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）