Polymorph Screening of API by Crystallization

摘要：

Many chemical substances, especially pharmaceuticals, can be crystallized in different crystal forms, a phenomenon known as polymorphism. Polymorphic forms can exhibit different chemical and physical properties, which has directed and significant influence on the product performance in pharmaceutical, chemical and food industry and continues to pose a challenge to scientist in producing product of consistent quality. Concurrently, it provides a unique opportunity, to engineer solid to get new valued materials. Knowledge of solid-state properties and the identification of polymorphic forms are hence critical in the pre-clinical stage, due to the biopharmaceutical, regulatory and intellectual property implication. In new development trend, polymorphism screening which provides a general overview of polymorphic forms, is a very necessary and potential technology.

关键词： polymorph screening transformation API crystallization

作者: Kyeong-Sill Lee Aeri Park Kwang-Joo Kim

作者单位: Crystallization Process & Engineering Laboratory, Department of Chemical Engineering,Hanbat National Crystallization Process & Engineering Laboratory, Department of Chemical Engineering, Hanbat Nationa

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 24-25

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）