Pharmaceutical Cocrystals as New Solid Forms: Screening,Characterization and Polymorphism
Pharmaceutical cocrystals have emerged rapidly as a new class of active pharmaceutical ingredient (API) solids with great promises and advantages, in addition to polymorphs, salts, solvates/hydrates and amorphous. This new branch of API has remarkably impacted the field of pharmaceutical research in the academic level by broadening the intrinsic values of APIs in terms of potential expansion of intellectual property and polymorphic variety, as well as enhancement of physiochemical properties, e.g. solubility, dissolution profile, stability. Potential industrial adaptation of this class of crystalline materials could be made possible in the near future too. A great deal of research has been dedicated to explore the crystal engineering design strategies that facilitate supramolecular synthesis of new crystalline phases (cocrystals) of APIs and cocrystal formers. However, few attempts have been made in understanding the equilibrium phase behavior and phase transition kinetics of the solutions of API and cocrystal former. Our group has developed a new method to predict a priori the cocrystal forming tendency between an API and cocrystal former. This method focuses on characterization of intermolecular interactions between API and cocrystal former in solutions using self diffusivity as a probe. This technique is useful for screening of potential cocrystal forming pairs before performing the time-consuming crystallization experiments.
Pui Shan Chow Srinivasulu Aitipamula Guangwen He Reginald B.H. Tan
Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science,Technology and Research), Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research)
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
28
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）