The Effect of Crystal Growth rates on Impurity Incorporation:A New Mechanism
A large number of pharmaceutical molecules are produced using crystallization as either a purification step or a polishing step, and in many cases both. Crystallization is a convenient operation for purification and polishing since most active pharmaceutical ingredients are crystalline solids under ambient conditions and because crystallization from solution can often result in very high purity products from a single stage operation. Since most crystalline products, and food and pharmaceutical products in particular, are required to be produced at very high purity levels, the incorporation of impurities into the crystal is a critical problem for production of an acceptable product. It has long been known that high crystal growth rates during industrial crystallizations can have a detrimental effect on the level of impurities in the crystal. There have been a number of mechanisms discovered that describe possible reasons for the increased incorporation, including enhanced impurity concentrations at the surface of the crystal, and incorporation of liquid inclusions into the crystal.
crystal growth impurity incorporation crystal growth rate history
Adrian E. Flood Arwut Promraksa Philip A. Schneider
School of Chemical Engineering, Suranaree University of Technology, Nakhon Ratchasima 30000,Thailand School of Engineering and Physical Sciences, James Cook University, Townsville,QLD 4811, Australia
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
34-37
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）