Protein Micro-spheres for Pulmonary Drug Delivery

摘要：

A new supercritical fluid (SCF) technique was developed for the preparation of micro-spheres for pulmonary drug delivery (PDD). This technique based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as model compounds to evaluate this SCF process efficiency. An aqueous solution of sample drug with a co-solvent was sprayed into high pressure carbon dioxide that extracts the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.

关键词： supercritical fluid particle design pulmonary drug delivery micro-spheres

作者: Sun Yongda

作者单位: Tianjin Crystec Pharmaceutical Technology Limited, Tianjin 300457, China

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 65-69

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）