Solubility and solvated behavior of L-Phenylalanine anhydrate/monohydrate in the presence of additives
Additives are used in the industrial crystallization of L-Phenylalanine to reduce solubility and thereby to enhance the recovery from aqueous solutions in which L- phenylalanine has been synthesized. Earlier research had shown that the crystal form obtained from such solutions can be either the anhydrous or the monohydrate form of L-phenylalanine. In this study, solubility of L-phenylalanine anhydrate and monohydrate in the presence of additives (potassium chloride, ammonium sulfate, sodium sulfate, and sodium chloride) was experimentally measured by a synthetic method at temperature ranging from 293.00 K to 328.00 K. It was found that over certain ranges of temperature and additives concentration, the additives plays important role in determining solubility reduction which had not been elucidated. Furthermore, at the crossing point from solubility curves, a transition temperature can be obtained between one stable crystal form and another, which has not also been reported.
L-Phenylalanine Solubility solvated behavior additives
Han Ye Wang Zhanzhong
School of Agriculture and Biological Engineering, Tianjin University, Tianjin 300072
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
100-107
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）