Polymorphic Transformation of Pravastatin Sodium Monitored Using Combined on-line FBRM and PVM

摘要：

Polymorphic transformation of pravastatin sodium in a mixture of isopropanol and water was studied by use of on-line FBRM and PVM. It is shown that the form A polymorph transformed to the stable polymorph, form B. It was speculated that in the transformation process there was an agglomeration and breakage phenomenon. The transformation mechanism was identified as solution-mediated phase transformation. Influences of temperature, solvent composition and stirrer speed on the transformation process were examined. It can be seen from the FBRM monitoring results that higher temperature, larger ratio of water to isopropanol and higher stirrer speed can increase the transformation process.

作者: Jia Chunyan Yin Qiuxiang Zhang Meijing Wang Jingkang Shen Zhonghua

作者单位: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 114-125

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）