Polymorph Control of Carbamazepine by SCF Techniques

摘要：

The methods to control carbamazepine polymorphs with supercritical fluid (SCF) techniques were executed. Form Ⅰ and Ⅱ were produced with solution enhanced dispersion with supercritical fluids (SEDS) process; and form Ⅲ produced with supercritical antisolvent (SAS) process. Pure form Ⅱ was generated from dichloromethane with the conditions of CO2 flow rate 10 mL/min, pressure 15 MPa and temperature 45℃. The transition temperature between form Ⅱ and Ⅰ was 193.0℃.

关键词： carbamazepine polymorph control SEDS SAS

作者: Liu Junwei Yin Lei Sun Yongda

作者单位: Tianjin Crystec Pharmaceutical Technology Ltd, Tianjin 300457, China

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 155-158

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）