Effects of Self-Assembled Monolayers on Crystal Polymorphs
The ability to predict and control crystal polymorphism is critical, and the control of crystal polymorphism has many practical applications such as in solid-state chemistry, material science 1, dyes 2, specially pharmaceuticals applications3. Self-assembled monolayers or multilayers (SAMs) have been successfully used as an interface to control crystal polymorphic form 1,4. Many reports have indicated that polymorph selectivity and nucleation density can be varied by interfacial chemical functionalities of SAMs. For example, Yitzhak Mastai et al used L-AAPP-SAMs on the Au substrate to control the crystallization of L-glutamic acid1; Jennifer A. Swift et al used 4’-X-mercaptobiphenyls (X=H, I, and Br)-SAMs on the Au substrate to control the crystalline form of 1,3-bis(m-nitrophenyl) urea4. Jennifer A. Swift 5 et al reported that the less stable orthorhombic phase can be selectively grown on 3’-X-4-mercaptobiphenyl (X=NO2，I) self-assembled monolayer templates. Michael D. Ward6 et al reported that nucleation rates of malonic acid (HOOCCH2COOH) were significantly rapid on SAMs terminated with carboxylic acid groups on gold surfaces.
Ren Yan Zhang Jinli Li Wei
School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
171-172
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）