Effects of Ionic Impurities on Crystallization of Cobalamin
The effects of ionic impurities on the crystallization process are well-known but often difficult to characterize and quantify, particularly on crystal growth. In this paper, the influence of two typical ionic impurities (Na+ and Mg2+) is investigated with an on-line FBRM (focused beam reflectance measurement) technique. The on-line FBRM can be applied to monitor dynamic change of particle size and counts during crystallization. This technique has largely gained attention in aspects of development and control of the crystallization process. In this system, the on-line FBRM is used as a tool for monitoring crystallization process of cobalamin by measuring the chord length distribution of particles and the particle counts and quantifying ionic impurities effects on crystal growth rate. It is noted that impurity Mg2+ has a more significant effect than that of Na2+ in crystal growth of the whole crystallization process. From microscopic observation of crystals, Mg2+ has an obvious effect on crystal habit, while Na2+ has little effect. In addition, the crystal habit changes can be monitored by PVM. Understanding these effects is helpful to aid optimization and improve process control.
Ionic Impurities Cobalamin FBRM PVM
Shao Baoli Chen Huia Wang Shuanga Liang Baochena Xu Shenmin
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin, 300384 School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
173-179
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）