Study on the Process of Reactive Crystallization of Clopidogrel Bisulfate
In this article, the phenomena of polymorphic transformation is revealed in the process of preparation of clopidogrel, which was achieved by reactive crystallization with acetone as the solvent In the process, we sampled in the regular time, and then identified with X-ray powder diffraction analysis. The result showed a transformation from polymorph I to polymorph II, as is reported form II is more stable than form I in thermodynamics. For further study, we observed the sample by SEM, and found that form I is plate-like while form II is club-shaped, both coalesced dramatically. In addition, much work was done in order to control the process of the transform, and the discipline was disclosed that the occurrence was delayed with temperature decrease and concentration increase. By further research, we explained this discipline, which provided a theoretical foundation for the production of this drug.
Clopidogrel bisulfate polymorphic transformation temperature supersaturation SEM
Song Liangcheng Wang Jingkang Gong Junbo
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
183-190
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）