A Novel Approach to Investigate the Primary Homogeneous Nucleation Kinetics of Anti-solvent Crystallization

摘要：

A novel approach is presented to investigate the primary homogeneous nucleation kinetics for the anti-solvent crystallization of Deflazacort in binary n-hexane+ethyl acetate, n-hexane+acetone solvent systems at 303.15 K using Laser Monitoring Technique. This method is based on the classical theory of 3D nucleation and the assumed power-law relation between the particle number density (N/V) and the opacity detected by Laser Monitoring Technique. The transmittance of laser beams is correlated with time to obtain a series of curves for both systems using the Boltzmann equation. The primary homogeneous nucleation kinetics is interpreted by the relation between the calculated slope of these curves at constant transmittance and the initial supersaturation ratio. The crystal-solution interfacial tension γ and the surface entropy factor f can be calculated from the kinetic parameters.

关键词： primary homogeneous nucleation kinetics anti-solvent crystallization Deflazacort crystal-solution interfacial tension surface entropy factor

作者: Wang Peng Gong Junbo Wang Jingkang Zhang Meijing

作者单位: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China；State Key L School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China； State Key

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 214-224

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）