Pharmaceutical Cocrystal and its Application
The first appearance of cocrystals can be traced back to the 60s of last century. But only within the last decade have cocrystals found their place in pharmaceuticals, primarily due to their ability to improve drug solubility and dissolution rate and increase the stability of drugs without compromising the structural integrity of the active pharmaceutical ingredient (API) and thus, possibly, the bioactivity. Besides these, the development of cocrystal can help us to get the independent intellectual property rights. This article will introduce us the definition of cocrystals, talk about how to choice the guest molecule of cocrystals, and present the influence of pharmaceutical cocrystal on the melting point, solubility and the mechanical properties.
pharmaceutical cocrystal definition guest molecule application
Xu Shen-min Wei Hong-yuan
School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072，China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
250-254
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）