Self-Assembled Iron Ozide Core for the Synthesis of an Intrinsic Quick-Magnetophoretic Core-Shell Superparamagnetic Nanoparticles and their in vivo Study

摘要：

A magnetically-induced targeted delivery of drug or gene is an interesting method to enhance the drug enrichment at the target site and bioavailability and to reduce the side effect or toxicity of the drug or gene with the help of an external magnetic field 1-3. Magnetic nanoparticles, composed of a magnetic component (e.g. iron oxide/magnetite) and a biocompatible component (e.g. dextran, starch), offer a potential method for tumor drug delivery with benefits that extend beyond the enhanced permeation retention (EPR) effect. These additional advantages originate from such specific properties of magnetic nanoparticles as magnetic responsiveness and MRI visibility 4. Obviously it is always attracting and expected for the above goal to design such a nanoparticle with high-magnetophoretic mobility, or a strong response to an external magnet field.

关键词： Magnetophoresis Superparamagnetics Core-shell structure MRI

作者: Yu Faquan Zhang Lei Sun Kai Allan E. David Beata Chertok Victor C. Yang

作者单位: Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor,Michig Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor,Michig Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor,Michig Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michi

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 263-266

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）