Degradation Kinetics in Aqueous Solution of Cefurozime Sodium

摘要：

The degradation kinetics in Aqueous Solution of Cefuroxime Sodium was investigated by a HPLC method under different conditions (concentration, temperature, and EDTA disodium salt solution). Cefuroxime sodium stability had little to do with its initial concentration, but showed lower stability as increasing temperature. Cefuroxime sodium stability was found satisfactory (<10% degradation) for 26h, 19.3h, 8.4h, 4.0h, 2.5h if kept at a temperature of 15 , 25 ℃ ℃, 35℃, 39℃， 45℃h respectively. The degradation rate did not change much，even the color change slowed in EDTA disodium salt solution. Meanwhile, there was a difference from chromatogram, that is, at about 2min, an obvious characteristic peak appeared.

关键词： cefurozime sodium degradation kinetics initial concentration temperature EDTA.2Na

作者: Zhao Ying-ying Wang Jing-kang Hou Bao-hong Jiang Xiao-bin

作者单位: State Key Laboratory of Chemical Engineering, Chemical Engineering Research Center,School of Chemica State Key Laboratory of Chemical Engineering, Chemical Engineering Research Center, School of Chemic

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 287-293

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）