Crystal Modification of Rifapentine Using Different Solvents
Rifapentine crystals with different habits were prepared by recrystallization from selected solvents, such as methanol, ethanol, chloroform and acetic acid. Scanning electron microscope, X-ray powder diffractometry, IR spectrometry and differential scanning calorimetry were used to investigate the physicochemical characteristics of the prepared crystals. The comparative dissolution behaviors of the newly developed crystals and the rifapentine without being treated were also studied. The results show that the newly developed crystals were different from each other with respect to physical properties but identical chemically. Needle-shaped crystals were obtained from methanol and ethanol, chloroform solvents, and the block-shaped crystals were obtained from acetic acid solvent. X-ray diffraction spectra and differential scanning calorimetry investigation on those developed crystals, clearly indicate that rifapentine have different crystal modification. When the crystal obtained from acetic acid, the change of crystal habit was originated from the crystal structure modification. The dissolution rate of newly developed crystals was found to be higher than the rifapentine without being treated. However, the modified crystal obtained from acetic acid shows the lowest dissolution rate.
Rifapentine Recrystallization Physicochemical characterization
Zhou Kun Li Jun Luo Jianhong Zheng Dongsheng
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
303-312
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）