Functional Nanoparticles Self-assembled from Amphiphilic Copolymer as Drug and Gene Carriers
Amphiphilic copolymers, generally composed of biodegradable hydrophobic polymer blocks such as polyesters, polyanhydrides or poly(amino acids) covalently bonded to a biocompatible hydrophilic block, typically PEG, can self-assemble into nanoparticles(NPs) with hydrophobic core and hydrophilic shell(Fig.1A), which have attracted a great deal of attention as hydrophobic drug carriers in terms of their ability to enhance the water-solubility of many hydrophobic drugs. Besides the cationic double hydrophilic copolymer complex NPs with gene(Fig.1B), cationic nanoparticles self-assembled from amphiphilic cationic copolymers also have recently received large interests as promising carriers for DNA or RNA delivery(Fig.1C). The NPs self-assembled from amphiphilic copolymers possess a remarkably lower critical micellar concentration, the entangling hydrophobic segments in the core provide a dynamic stable state to NPs, and the hydrophilic PEG shell not only sterically stabilize the NPs but also provide the “stealth property of avoiding recognition by the RES to achieve longevity with the payload in the blood circulation. Furthermore, the NPs self-assembled from amphiphilic copolymers have a high loading capacity for hydrophobic drugs and genes and form smaller sized NPs with very narrow size distribution. Beyond above advantages, the amphiphilic copolymers NPs have been considered as a novel choice in the field of drug targeting delivery by functionalization of the outer surface.
Dong Anjie Yao Fanglian Deng Liandong Xing Jinfeng
Department of Polymer Science and Technology, School of Chemical Engineering and Technology,Tianjin Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
337-339
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）