Simutaneous Determination of Nine Active Components in Traditional Chinese Medicine ‘Xue-Fu-Zhu-Yu’ Capsule by LC-ELSD
A reliable and accurate LC-ELSD method was developed for simultaneous determination of eight constituents in ‘Xue-Fu-Zhu-Yu’ capsule, a widely used prescription of traditional Chinese medicine (TCM). The chromatographic separation was performed on a Symmetry C18 column (150mm×4.6mm, 5.0μm) using gradient elution of acetonitrile, methanol and water (containing 1.0% acetic acid). The flow rate was 0.5 mL/min and the temperature of column was 30℃. A good linearity correlation (R2>0.9954) was obtained over the investigated concentration ranges. Recoveries of the nine components varied from 95.47 to 103.12% (RSD %< 5.0%). The validated method was successfully applied to the simultaneously determination of these active components in‘Xue-Fu-Zhu-Yu’ capsule from different production batches.
Column liquid chromatography Quantitative analysis Traditional Chinese medicine Xue-Fu-Zhu-Yu’capsule
Ying Gao Wenyuan Gao Fengge Li Xinying Yang Xuan Dong
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Medical C School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Tianjin Hongrentang Pharmaceutical Co.,Ltd., Tianjin 300122, China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
340-349
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）