Preparation and in vitro Antineoplastic Activity of Norcantharidin-Loaded Galactosylated Chitosan Nanoparticles

摘要：

1 Objective The aim in this study was to synthesize a novel chitosan derivative, galactosylated chitosan (GC), and prepare norcantharidin-associated galactosylated chitosan nanoparticles (NCTD-GC-NPs) with GC as hepatocyte-targeting carriers and norcantharidin (NCTD) as model drug against primary liver carcinoma. It was expected that NCTD-GC-NPs could be specifically recognized by asialoglycoprotein receptor (ASGP-R) of hepatocyte, and a dual hepatocyte-targeted delivery for NCTD, combine passitive targeting with active targeting, would be developed.

关键词： norcantharidin galactosylated chitosan nanoparticles hepatocyte-targeted delivery cellular uptake cytotozicity tumor-bearing mice

作者: WANG Qin ZHANG Liang HU Wei HU Zhanhong ZHANG Xuenong

作者单位: Department of Pharmaceutics, School of Pharmacy, Soochow University Department of Biopharmaceutics, School of Pharmacy, Soochow University, Jiangsu, Suzhou 215123, Chin Department of Pharmaceutics, School of Pharmacy, Soochow University Suzhou Liyuan Medical Technology

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 364-365

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）