Tazol-loaded Nanoparticles Based on MPEG-B-PCL as Drug Carrier and Emulsifier
Taxol is one of the best antineoplastic drugs and has excellent effects for a broad spectrum of cancers especially for breast and ovarian cancers. However, due to its extremely poor solubility in water and other pharmaceutical regents, an adjuvant called Cremophor EL (50:50 ethanol-polyoxyethylated castor oil) has to be used for its clinical administration, which may cause serious side effects. Alternative dosage forms are thus necessary to overcome this problem. The use of biodegradable polymeric nanoparticles for delivery of taxol has advantages in enhancing therapeutic efficacy and reducing systemic side-effects. Amphiphilic block copolymers are usually used as drug carriers. The hydrophobic core may serve as a nano-reservoir for hydrophobic drugs, while the hydrophilic shell provides a protective coating between the core and the external medium and increases the physicochemical and biologic properties of nanoparticles, such as longer body circulation and efficient tumor accumulation. Therefore, we investigated taxol-loaded methoxy poly(ethylene glycol)-b-poly(ε-caprolactone)(MPEG-b-PCL) nanoparticles.
Zhang Yanting Hou Jingwen Guo Shengrong
School of Pharmacy, Shanghai Jiaotong University, Shanghai, 200240, China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
369-370
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）