Studies on the Self-assembled Proliposomes of Paclitazel

摘要：

PTX was employed as model drug, soybean lecithin as lipid material, combining with PEG modifiers, stabilizing agents and dispersing medium proportionally to prepare PSAP. Stability time, appearance of self-assembled PTX liposome and syringeability of PSAP were employed as factors to screen the preliminary formulation. On the basis of preliminary formulation, the central composite design (CCD)-response surface design (RSM) method was employed to optimize the formulation by using mean diameter, entrapment efficiency, polydispersity index and leakage percent as the factors. The results showed that optimized formulation of PSAP could be prepared with such compositions as drug loading 0.6%, drug/lipid ratio 1:30 and modifier A 16%.

作者: Zhou, Jianping

作者单位: China Pharmaceutical University, Department of Pharmacy, No. 24 Tongjiaxiang, 210009 Nanjing, China

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 372

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）