Significant Influence of Couette-Taylor Vortez on Phase Transformation of Sulfamerazine
1 INTRODUCTION Activity pharmaceutical ingredients (API) are made up of organic materials and almost have polymorphs which are different arrangements of the same chemical compound in solid state. They can have different characters as medicine such as solubility, density, melting point and chemical stability. Especially, the solubility, which is important factor in the pharmaceutical industry, is directly related to the bioavailability. Therefore, the control of polymorphs has recently become a hot issue a drawing a great deal of attentions in the pharmaceutical industry because of its importance in API formulation. 1 In general, the polymorph of API crystal being thermodynamically most stable is most favored to lunch in the market because it has the highest stability and the longest shelf-life during storage, processing and formulation. Therefore, the effective production of the stable form of the polymorphic API has been a great challenge in the crystallization technology. 2 One of methods producing the stable form of polymorphic API is a solvent mediated transformation based on dissolution of the meta-stable crystal and re-crystallization of the stable crystals due to the difference of solubility between the polymorphs.3 Frequently, however, the production of the stable form in the crystallization is frustrated due to the tardy process of the phase transformation. For example, the phase transformation of sulfamerazine from the meta-stable form (form-I) to stable form (form- II) is to take about 300hr in the solution.4 Therefore, in present study, it was attempted to promote the phase transformation of sulfamerazine by using a Couette-Taylor vortex in Couette-Taylor crystallizer. Also, the efficiency of the Couette-Taylor vortex on the phase transformation was compared with that of the turbulent agitation in mixing tank crystallizer.
Sulfamerazine polymorph solvent-mediated transformation Couette-taylor vortez phase transformation
Aleum Choi Woo-Sik Kim
Department of Chemical Engineering, Kyung hee University, Kyungki-do, 449-701, Korea
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
376-379
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）