Thermoreversible Gelation of Poly(ethylene glycol)/Poly (ester anhydride) Triblock Copolymer nanoparticles for Injectable Drug Delivery Systems
In recent years, temperature-sensitive systems which show sol-gel transition at body temperature have gained great interest, because they are generally liquid formulations and then form a semi-solid depot after injection into the desired tissue or organ 1-4. Due to their flowing nature, no surgery is required for placement and withdrawal and they can fill cavities or defects. At present, the main thermogelling polymers include Poloxamers5,6, copolymers of N-isopropylacrylamide7,8 and PEGylated aliphatic polyesters9-16. Other biodegradable thermogelling polymers including chitosan-based copolymers17-20, polyphosphazene-based copolymers21-23, cellulose-based copolymers24,25 and poly(ethylene glycol)–sebacic acid polyester26 were also studied. In this paper, an novel amphiphilic triblock copolymer (mPEG-b-P(OA-DLLA)-b-mPEG) was synthesized via melt polycondensation of mPEG, poly(octadecanoic anhydride) (POA) and ODLLA as shown in Table 1. The self-assembly behaviors of copolymers and the influences of temperature on the gelation of copolymer nanoparticles were studied.
Deng Liandong Liang Yanqin Xing Jinfeng Dong Anjie
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
380-382
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）