Solid Dispersion Facilitating the Osmotic Pump Delivery of Water-insoluble Drug

摘要：

Monolithic osmotic pump tablet (MOPT) is benefited by the simplified preparation process. Drug release from the MOPT depends on the drug water-solubility and dispersion rate in the polymeric matrix of tablet. As the low solubility of drug is one of the most important factors affecting the drug release process, many methods have been proposed to enhance the drug solubility. It was repoeted that inclusion complex was applied to promote drug solubility and stability in MOTS for water-insoluble drug. However, not all drugs could form inclusion complex and it may be more suitable to delivery drugs in suspension. In the present study, the MOPT composing drug solid-dispersion, which was widely used to increase the solubility, dissolution rate and bioavailability of water-insoluble drugs, was developed to facilitate the constant drug release from the MOPT.

关键词： solid dispersion monolithic osmotic pump tablet hydrozycamptothecin controlled drug release

作者: Jiang Guoqiang Yan Hongfei Chen huanhuan Ding Fuxin

作者单位: Department of Chemical Engineering, Tsinghua University, Beijing 100084, PRC

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 391-392

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）