The Absorption Mechanism of TCM Constitutes and Their Combination Dosage Form
To understand the GI transport mechanism and the interaction in vivo among TCM constitutes, some constitutes of TCM and their formulations were fully investigated based on the GI absorption and metabolism. Panax notoginseng Rg1, hydroxysafflor yellow A (HyA), ferulic acid (FA) and Chuangxiong essential oil (CEO) were studied in their physicochemiacl and biopharmaceutical properties. A new traditional Chinese combination preparation(TCCP) was developed according to constituents combination principle. In order to provide the reasonable basis, the difference of pharmacodynamics and pharmacokinetics between effective constituents group (SECG) of new TCCP and original TCCP (SXT), the later was composed of crude extracts Chuangxion root and red flower and the powder of panax notoginseng. Moreover, the pharmacodynamics of SECG was compared with SXT. The results demonstrated both preparations showed similar effect on anticogulated blood, antithrombus and myocardial preservation experiments. Their dose-response relationship and result of action are similar. However, some pharmacokinetics parameters of active ingredients had significant change after oral administration of different combinations of SXT constituents. The oral bioavailability of HyA, FA and Rg1 was improved by 6.056, 2.854 and 2.055 folds when CEO was co-administered (25 mg/kg), respectively. CEO can significantly decreased the transepithelial electrical resistance (TEER) and influenced the distribution and expression of Claudin-1 to open the tight junctions.
Panaz notoginseng saponins Hydrozysafflor yellow A Ferulic acid constituents combination Immunofluorescence method Microemulsion Enhanced absorption
Ping Qineng Qi Jianping Xiong Jing Wang Shujing Sun Mingjie
China Pharmaceutical University
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
398
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）