Evaluation on Anti-Ozidant Activity in Vivo of Ferulic Acid Liposome for Drug Delivery to Brain
Animal model of ischemia/reperfusion was set up to value the antioxidant activity in vivo and the activity of SOD, T-AOC and the content of MDA were used as index. Ligustrazine was used as positive control. The SOD activity and T-AOC content of Ferulic acid liposome (FAL) group was higher than that of Ligustrazine. The SOD activity of RGD-FAL (RGD-mediated ferulic acid liposome) was 3-folder and 3.38-folder higher than that of FAL and Ligustrazine, respectively (Fig.1); T-AOC content of RGD-FAL was significantly higher than that of FAL and Ligustrazine, respectively (Fig.2). MDA content of RGD-FAL was lower than that of FAL, FA injection and Ligustrazine (Fig.3). The antioxidant activity in vivo of RGD-FAL was significantly greater than that of FA injection, liposomal FA and Ligustrazine and has a protect effect on I/R (ischemia/reperfusion). Thus, this strategy is a promising approach due to it can deliver drug directly to brain and allow a better protective effect in vivo.
brain-targeting ischemia/reperfusion ferulic acid RGD peptide
Qin Jing Dawei Chen Jianxin Wang Haiyang Hu Limei Han
School of Pharmacy, Fudan University, Shanghai Department of Pharmaceutics,School of Pharmacy, Shen Department of Pharmaceutics,School of Pharmacy, Shenyang Pharmaceutical University School of Pharmacy, Fudan University, Shanghai
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
399-400
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）