Recent Advances of Penetration of Biological Macromolecular Drugs in Transdermal Drug Delivery System

摘要：

The research of biological macromolecular drugs in transdermal drug delivery system (including transdermal and mucous administration) always is a crucial and difficult field in pharmaceutics research, because this drug generally displays characteristics including high molecular weight, high hydrophilic properties, poor stability, short biological half-life, enzymatic degradation in the gastrointestinal tract and the hepatic first-pass metabolism effect for oral administration. Therefore, The main route in clinical therapy is conducted by injection or implantation, which cause great agony and inconvenient to patients. Dermal or mucous surface drug delivery can not only avoide the destroying of gastrointestinal environment to drug molecules and the first-pass metabolism effect, efficiently solving the problem that biological macromolecular drugs easily lost activity leading to low bioavailabilities and short biological half-life, and sustained a long-term steady rate of drug delivery and plasma concentration, as well as reduce systemic side effects; but also avoid the disadvantage of biological macromolecular drugs by injection or implantation, and provide patients with an easier and more convenient route for drug administration. However, there also are some limitations in transdermal and mucous drug delivery, such as requiring the drugs with Molecular weight lower than 500, melting point less than 300℃, and a certain distribution coefficient. It is difficult for aqueous macromolecules to permeate skin or mucous membrane due to its low permeability, high hydrophilicity and physiological structure barrier. A key problem that biological macromolecular drugs permeate skin or mucous membrane is to overcome the barrier function of skin or mucous membrane and improve drug permeability. Therefore, more and more studies have been carried out to increase drug permeability through the stratum corneum or mucous membrane, to achieve therapeutic levels.

关键词： transdermal drug delivery system biological macromolecular drugs chemical and physical enhancing permeation method

作者: Shen Dandan Huang Hua Zhang Tao

作者单位: Chongqing MedicalSciences University, Chongqing 400016 Chongqing Research institute of Pharmaceutical industry, Chongqing 400061

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 401-403

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）