A Novel Cataplasma Matriz of Traditional Chinese Medicine
The present cataplasma matrices are most suitable for water-soluble drugs, and incompatible with the liposoluble active ingredient. The aim of this paper was to develop a cataplasma matrix that can be applicable to different drugs. The gellan gum and the konjaku were employed as the scaffold materials of the matrix. Mechanical properties of cataplasma matrices were affected primarily by the amounts of gellan gum, xanthan gum, konjaku and glycerin. The amounts of polyacrylic acid sodium and oligosaccharides influenced both the adhesive property and elongation of the matrix. The increase of the amount of the Xanthan gum caused a decrease of the elongation and the tensile strength of the matrix. Further, the elongation increased while the tensile strength decreased when the amount of glycerin rose. The formula of cataplasma matrix was optimized by the orthogonal method. A formulation was suggested with gellan gum 0.4 g, xanthan gum 0.03 g, konjac glue 0.1 g, glycerin 4 g, GAT 6 g, GAE 6 g, polyacrylic acid sodium 0.22 g, and sorbitol 3 g. The 180° peel strength, the tensile strength and the elongation at break were 3.043 N, 0.275 MPa and 91.05%, respectively. Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcumin, which were used as the models of hydrophilic, poor-water-soluble and hydrophobic ingredients. The drug contents could reach 4.12%, 2.42% and 3.75% while the in vitro release rate were measured as, 361.79, 55.85 and 104.41 μg·cm-2·h-1 for baicalin, berberine and curcumin respectively. These results indicated that the obtained matrix had good drug-compatibility and drug-release properties for different ingredients.
Cataplasma Novel matriz Traditional Chinese Medicine In vitro release
TIAN Jing ZHANG Xiaolei ZHOU Xueqin
Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
412-420
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）