Konjac Glucomannan and Xanthan Gum as Compression Coat for Colonic Drug Delivery:Ezperimental and Theoretical Evaluations
A large number of polysaccharides already have been studied for their potential as colon-specific drug carrier systems. It has been reported that the KGM-hydroxypropyl methylcellulose compression coated tablets was a promising delivery system for drugs to be delivered to the colon. Furthermore, it was shown that the synergistic interaction between konjac glucomannan (KGM) and xanthan gum (XG) in the gel phase affects on the drug diffusion, which can effectively retard the drug release from the matrix tablets. In this paper, compression coated tablets with polysaccharide mixtures of KGM and XG as the controlled release materials were investigated and the release mechanism was analyzed. Cimetidine is used as the model drug in this paper. β-mannanase was employed to mimic the enzymatic attack of the bacterial enzymes in the colon. KGM of coating was degraded by β-mannanase in mimic colon solution, which improved drug release. The aim of our work was to describe the release process of drug from compression coated tablets and the degradation properties of KGM and polysaccharide mixtures of KGM and XG.
Wang Kang Fan Jiangyang Liu Yanjun He Zhimin
Enzyme Technology Laboratory, Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
423-427
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）