Preparation and Evaluation of Trimethylated Chitosan Modified Biodegradable Nanoparticles as A Novel Brain Targeting Drug Carrier

摘要：

A large number of drugs delivered to the central nervous system are impeded by the tight restriction of the blood-brain barrier (BBB). Consequently, many brain diseases are undertreated. Coupling drugs with specific brain targetor results in absorption-mediated transcytosis (AMT) through the BBB. Trimethylated chitosan (TMC) is a quaternized chitosan derivative. As a cationic ligand, TMC may facilitate the active transport of nanoparticles via AMT pathway. In light of the above, TMC modified biodegradable nanoparticle was developed as a novel drug carrier for brain targeting and its brain-targeting effects were investigated.

关键词： nanoparticle brain targeting blood-brain barrier trimethylated chitosan neuroprotective effects Co-Q10

作者: Wang Zhaohui Wang Chunyan Hu Yanchen Sun Changshan Wang Zhanyou Wang Siling

作者单位: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016,Liaoning Province, Department of Histology and Embryology, China Medical University, Shenyang 110001,Liaoning Province, Department of Histology and Embryology, China Medical University, Shenyang 110001, Liaoning Province

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 429-432

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）