Conzyme Q10-loaded Liposomes Coated With Trimethyl Chitosan Prevent Cataractogenesis in Vitro and in Vivo
Cataract refers to the opacification of the lens of the eye. Apoptosis of lens epithelial cells is implicated in the pathogenesis of several types of cataract formation1. Various biochemical changes associated with selenite-induced cataract have been reported. Among them, superoxide dismutase was found to act as defense enzymes to the oxidative stress in cataract2, 3, GSH is one kind of small peptides for scavenging O2 -, H2O2 and LOOH and malondialdehyde is produced from lipid peroxidation. Coenzyme Q10 (CoQ10) functions as a well-known electron carrier and efficiently protects membrane phospholipids and mitochondrial DNA from free-radical-induced oxidative damage4-6. In view of the antioxidant properties of CoQ10, and since oxidative stress has been implicated in cataractogenesis, N-trimethyl chitosan chloride (TMC)-coated liposomes containing CoQ10 were investigated to exhibit anticataractogenic potential for the first time. Firstly, TMC (TMC 601 and TMC 602 with degree of quaternization about 65 %, MW 100KDa and 450KDa, respectively) were employed for reducing rapid precorneal drug loss7, 8. Secondly, the protective effects of CoQ10 in vesicles composed of TMC against cataract were investigated both in vitro and in vivo.
Coenzyme Q10 N-trimethyl chitosan chloride cataract apoptosis biomarker
Zhang Jing Wang Zhanyou Jiang Tongying Wang Siling
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Cell Engineering, China Medical University, Shenyang 110001, China
国际会议
International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)
天津
英文
449-453
2009-09-05（万方平台首次上网日期，不代表论文的发表时间）