Evaluation of Chitosan Oligosaccharide Nanoparticles Prepared by A Novel Microemulsion-Coacervation Method

摘要：

Chitosan oligosaccharide（COS）is the low molecular weight chitosan, which is more readily soluble than chitosan. Both chitosan and COS are biodegradable, biocompatible, and low-toxic materials, which are very popular in drug delivery system, especially as materials for developing micro/nanoparticles. The present approach for preparing chitosan nanoparticles, however, still have some drawbacks, such as low encapsulation rate, high toxicity induced by abundant emulsifier and cross linking agents. Herein, a novel microemulsion-coacervation technique was developed to prepare non-cross-linked chitosan oligosaccharides nanoparticles(COS-NPs). This technique is an improvement of emulsion cross-linking way which often used to prepare chitosan–based microspheres. The major improvement is avoiding toxicity from abundant emulsifier by adding co-emulsifier and glutaraldehyde as chemical crosslinker. Furthermore, the obtained nanoparticles were characterized and evaluated by its drug release mechanism, in vitro cytotoxicity and in vivo tissue distribution.

关键词： Chitosan oligosaccharide nanoparticles microemulsion- coacervation method evaluation

作者: Zhang Xiaowei Jiang Tongying Li Yuting Wang Tianyi Wang Siling

作者单位: Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, China

会议类型: 国际会议

会议名称: International Symposium on Crystal Engineering and Drug Delivery System 2009(2009晶体工程与药物传送系统国际会议)

会议地点: 天津

会议语种:英文

页码: 454-458

在线出版日期: 2009-09-05（万方平台首次上网日期，不代表论文的发表时间）