Chronic Ezposure of Engineered Silica Nanoparticles to Carassius Auratus Gill: Ozidative Damages and Influence of Synthesis Method
In order to survey the potential health risk of engineered silica nanoparticles, Carassius auratus was exposed to nanosized silica of different synthesis methods: fumed silica, and colloidal silica. A fix dose of 1mg/mL, which is equivalent to concentration of silica nanoparticles applied in environmental decontamination, was designed to perform 5-week chronic exposure. No significant changes of total antioxidant capacity (TAC) were observed after 5-week exposure, but significant decreases of catalase (CAT) activity were detected in fish gill, when compared with the controls (p<0.01). The declined activity of CAT indicates enhanced risk of being suffered invasion from free radicals. Comparing with colloidal silica and the control groups, fumed silica exposure induced significantly increase of malonyldialdehyde (MDA) in fish gill with a mean particle size of 441nmq (p<0.01; p<0.01), whereas colloidal silica with a mean particle size of 16.9nm led to no significant redox changes after 5-week exposure. The findings indicate that synthesis method may also greatly influence the final biological effect of engineered silica nanoparticles. Systematic studies on particle size, metal composition, synthesis method, surface treatments and other factors which might influence biological effects of engineered nanoparticles (ENPs) are required. Such studies will be helpful to advance our understandings on adverse effects of ENPs and therefore to minimize their potential adverse effects.
engineered silica nanoparticles chronic ezposure ozidative stress synthesis method
LIU Yang JI Xiuling LI Rong
School of Environmental Science & Engineering,Donghua University,Shanghai 201620,China
国际会议
2009 International Symposium on Environmental Science and Technology(2009环境科学与技术国际会议)
上海
英文
293-296
2009-06-02（万方平台首次上网日期，不代表论文的发表时间）