Characteristics of Urinary Monohydrozy Polycyclic Aromatic Hydrocarbons Metabolites (OH-PAHs) in Pregnant Women
The internal exposures to polycyclic aromatic hydrocarbons (PAHs) of pregnant women from Shanghai were assessed through the detection of urinary PAHs metabolites. Several monohydroxylated PAHs (OH-PAHs) were monitored, and the mean concentrations of 2-Hydroxynaphthalene (2-OHNap), 2-Hydroxyfluorene (2-OHFlu) and 1-Hydroxypyrene (1-OHPyr) were 0.57 ìg/mmol creatinine, 0.32 ìg/mmol creatinine and 0.06 ìg/mmol creatinine, respectively. Relative high concentrations, especial 2-OHFlu, can be found in Shanghai compared with previous studies. The profile of different OH -PAHs was calculated and 2-OHNap was the main component. The concentration of 1-OHPyr is almost one order of magnitude lower than that of 2-OHNap. All the correlation studies indicate that monitoring of 2-OHNap, 2-OHFlu and 1-OHPyr as multiple biomarkers are more suitable than 1-OHPyr. Smoking can obviously affect the concentration level of 2-OHNap in urine samples, but no significant difference is observed between levels of 2-OHFlu and 1-OHPyr in smokers and nonsmokers. The concentration of 2-OHNap seems to be more sensitive to cigarette smoke than other analytes.
monohydrozy-PAH metabolites urine pregnant woman HPLC
ZHOU Jing ZHANG Xiaolan YU Zhiqiang WU Minghong YANG Zujing SHENG Guoying FU Jiamo
Institute of Environmental Pollution and Health,School of Environment and chemical Engineering,Shang State Key Laboratory of Organic Geochemistry,Guangdong Key Laboratory of Environment and Resources,G Department of Obstetrics andGynecology,Xinhua Hospital,Medical College of Shanghai Jiaotong Universi Institute of Environmental Pollution and Health,School of Environment and chemical Engineering,Shang
国际会议
2009 International Symposium on Environmental Science and Technology(2009环境科学与技术国际会议)
上海
英文
2384-2389
2009-06-02（万方平台首次上网日期，不代表论文的发表时间）