Synthesis and Tozicity of Polyozometalates Containing La and 5-fluorouracil

摘要：

Two novel polyoxometalates containing rare earth element La and organic group 5-fluorouracil C4H4FN2O2K11La(PW11O39)2·18H2O (FLPW) and K26(C4H4FN2O2)8La(SiW11O39)4·10H2O (FLSW) were synthesized and structurally characterized by elemental analysis, IR spectra, UV spectra and X-ray powder diffraction. The results indicate that the compound has the Keggin structure of heteropolyanion and the ring structure of 5-fluorouracil. With 5-fluorouracil for the positive control group, the ivtro cytotoxicity test of the compounds FLPW and FLSW were studied in human renal embryonic cell HEK293 by MTT method. The compound FLPW has lower toxicity in vitro than those of 5-Fu and FLSW with significant difference at low concentration.

关键词： polyozometalate 5-fluorouracil rare earth cytotozicity

作者: WANG Shuaishuai LIU Xia FENG Changgen

作者单位: School of Mechanic-electronic Engineering,Bejing Institute of Technology,Beijing 100081,P. R. China College of Science,China Agricultural University,Beijing 100094,China

会议类型: 国际会议

会议名称: 2009 International Symposium on Environmental Science and Technology(2009环境科学与技术国际会议)

会议地点: 上海

会议语种:英文

页码: 2456-2460

在线出版日期: 2009-06-02（万方平台首次上网日期，不代表论文的发表时间）