Comparative in Vitro Cytotozicity Assessment of Some Manufactured Nano-particulate Materials

摘要：

The aim of this study was to investigate the in vitro cytotoxicity and inflammation of human bronchial epithelial cells (BEAS-2B) after exposure to various type and size of nanoparticles such as Ag, Au, Fe203, TiO2, and CNT. The cell viability was dose-dependently reduced for all materials except Au. The cytotoxicity of Ag and MWCNT was increased due to their smaller size. We have found that the Ag, CNT and small size Fe203 lead to cellular toxicity but Au and TiO2 were not toxic compared to other nano-materials. Depending on the size, though cytotoxicity was not observed in >100nm size, but medium toxicity observed in 50-100nm and we confirm that the <50nm NPs be significant toxicity.

关键词： Nanoparticle Cytotozicity Inflammation BEAS-2B cell

作者: Ji-Yeon Yang Ji-Young Jangt Young-Wook Lim Soo-Hwan Kim In-Hong Choi Gang-Tak Lee Jin-Woo Chun Dong-Chun Shin

作者单位: The Institute for Environmental Research, College of Medicine, Yonsei University, 134 Shinchon-dong, Dept. of Microbiology, College of Medicine, Yonsei University, 134 Shinchon-dong,Seadaemun-gu, Seoul Dept. of Chemical Engineering, College of Engineering, Yonsei University, 134 Shin-chon-dong, Seadae Dept. of Chemical, College of Science, Yonsei University, 134 Shinchon-dong, Sea-daemun-gu, Seoul, K The Institute for Environmental Research, College of Medicine, Yonsei University, 134 Shinchon-dong,

会议类型: 国际会议

会议名称: The 2nd International Conference on Risk Analysis and Crisis Response(第二届风险分析与危机反应国际学术研讨会)

会议地点: 北京

会议语种:英文

页码: 720-723

在线出版日期: 2009-10-19（万方平台首次上网日期，不代表论文的发表时间）