Robustness Perspective on Network-based Prediction of Gene Essentiality
Essential genes are the genes that are indispensable to cell viability. It is very important to ascertain these genes for understanding the biological phenomena, as well as drug and therapy design. In the present paper, we understand the essential and nonessential genes from the perspective of robustness. Other than traditional homology study based methods, this article use structural analysis of functional subsystems of genome-scale metabolic networks. We give the structural analysis of the citric acid cycle as a case study, the result suggests that this systems-oriented method would help to ascertain gene essentiality.
Gene Essentiality Metabolic Network Robustness
Wei Liu Dewu Ding Nawen Li
Department of Modern Education Technology and Teaching, Ludong University, Yantai 264025, China Department of Mathematics and Computer Science, Chizhou College, Chizhou 247000, China Department of Design, Guilin University of Electronic Technology, Guilin 541004, China
国际会议
2009年中国控制与决策会议(2009 Chinese Control and Decision Conference)
广西桂林
英文
3871-3873
2009-06-17（万方平台首次上网日期，不代表论文的发表时间）