MUI: a new functional similarity measure for gene products based on Gene Ontology

摘要：

The Gene Ontology (GO) was widely used to annotate gene products, which provide a new way to analyze the relationship between the gene products. Many approaches based on GO were proposed to measure the functional similarity of gene products. In order to improve the accuracy, we proposed a novel method, MUI, to measure functional similarity of gene products combining the information of the interactions between the GO terms and the semantic similarity measures based on the information content. The dataset from OMIM database was used to evaluate these functional similarity measures including MUI, Max, Mean, and Schlicker method. The receiver operating characteristic (ROC) curve illustrated that MUI outperformed the other methods with lower false positive rate and false negative rate.

关键词： Gene Ontology functional similarity measures Semantics OMIM Databases ROC Curve

作者: Hu Qiang Zhang Zheng-Guo

作者单位: Department of Biomedical Engineering Institute of Basic Medical Sciences of CAMS,School of Basic Medicine of PUMC Beijing,China

会议类型: 国际会议

会议名称: The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 1-6

在线出版日期: 2009-06-11（万方平台首次上网日期，不代表论文的发表时间）