Modelling the dynamics of Anti-HBV Infection Therapy with Chinese Herbs
Effective treatment of chronic Hepatitis B virus (HBV) patients aims to prevent progression of chronic hepatitis B to cirrhosis, hepatocellular carcinoma, and eventually death. The use of mathematical modelling to explain the anti-HBV infection therapy has made a signi.cant contribution for understanding the dynamics of host cells, viruses, the immune system. Chinese herbs are playing important roles for anti-HBV infection treatment. Recently a new type of Chinese herbs (NTCH) has been proved to be effective for anti-HBV infection therapy. Based on a patients anti-hepatitis B virus (HBV) infection therapy clinical data with the NTCH and our previous modi.ed basic virus infection model 1, a new differential equation model with an immune variable is set up. The numerical simulations of the model show that the evolution of the HBV DNA of the model is agreement with in the patients clinic plasma HBV DNA levels. The model predicts that it needs to prolong the treatment time to 4.3 years to eliminate NTCH the HBV virus in the patients infected hepatocytes. Otherwise earlier cessation of the therapy will make the patients HBV DNA levels return rapidly.
hepatitis B Chinese Herbs anti-HBV infection therapy model
Yongan Ye Lequan Min
Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700,PR China Applied Science School University of Science and Technology Beijing Beijing 100083,PR China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）