When and where does the reentry Start in Long-QT syndrome? –A computer simulation study
Reentry is the main form of arrhythmia. To known when and where the reentry starts in Long QT Syndromes (LQTS) and its relation with M cells distribution, the Luo-Rudy dynamic ionic model (LRd00) of the mammalian ventricular action potential (AP) was used in a two dimensional transmural tissue sheets simulation. LQTS was simulated by reducing the membrane conductance of IKs for LQT1 and IKr for LQT2, and by altering the steady-state inactivation of the fast sodium current INa for LQT3. The endocardium was paced 10 times at a constant basic cycle length (BCL) of 500ms (S1), and following a 2000ms pause, a S2 stimulus was applied, or also a S3 stimulus was applied. The simulation was processed by changing shape, size and position of M cell domain, and S2S3 interval. We found that pause induced early after depolarization (EAD) started reentry near the boundary between endocardial domain and M cells domain. Only S3 stimulus that located in vulnerable windows could form reentry. The started position of the reentry depended upon the distribution of island of M cells and the position of extrasystole.
Long-QT syndrome Early afterdepolarizations M cells Reentry Computer simulation
Jin Yinbin Zhang Hong Yang Lin Yang Zhao
School of Electrical Engineering Xian Jiaotong University Xian 710049,PR China School of Medicine Xian Jiaotong University Xian 710061,PR China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）