Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility
The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.
breast cancer local gene network alcohol consumption microarray
Liangyu Meng Pengpeng Li Yun Wang Changlu Wang Zhiwei Wang Zhizhou Zhang
Teda Bio-X Center for Systems Biotechnology,Tianjin University of Science and Technology,Tianjin,Chi Teda Bio-X Center for Systems Biotechnology,Tianjin University of Science and Technology,Tianjin,Chi
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）