The properties of a compound nerve scaffold based on acellular-matriz and poly (lactide- co-glycolide)
With the development of tissue engineering for peripheral nerve regeneration, compound nerve scaffolds will be paid more attention in future. In this study, we attempted to fabricate a compound nerve scaffold with acellular pigskin and poly (lactide-co-glycolide) PLGA and characterized for its microstructure, in vitro degradation behaviour and biocompatibility. The microstructure of the scaffold was observed by Scanning electron microscope (SEM); Its in vitro degradation behaviour was evaluated by testing its max water absorption and ultimate mass loss; In vitro biocompatibility assessment was carried out to assess the morphology and viability of Schwann cells coculturing with the scaffold. According to the results, the scaffold was homogeneous and porous; its max water absorption was about 100.06％, its ultimate mass loss was about 9.05％ in PBS (pH=7.4) during 8 weeks; SCs could adhere to the scaffold and MTT assay confirmed more adhesion of Schwann cells on the scaffold than its control. It could be concluded that this compound scaffold will be a potential artificial nerve scaffold.
Compound nerve scaffold Acellular pigskin Poly (lactide- co-glycolide) Peripheral nerve regeneration
Xiaozhen Dai Shaoxi Cai Zhiling Xu Bin Liu Kaiwang Ma Xiaokun Li
College of Bioengineering,Chongqing University,Chongqing,China College of Life Science,Southwest University,Chongqing,China College of Medical technology and Engineering,Henan University of Science and Technology,Luoyang,Chi College of Pharmacy,Wenzhou Medical College,Wenzhou,China
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）