Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles
Fine and continuous composite medicated PAN/PVP fibers were prepared using wet spinning processes. The co-dissolving method was employed to prepare the spinning solution. The prepared fiberts had a diameter of 145±17 μm. SEM images showed that the fibers had a uniform and homogeneous structure with some nano drug particles aggregated on the fiber surface. X-ray diffraction analysis result suggested that ibuprofen existed in the fibers in an amorphous status. FTIR analysis result demonstrated the polymers and the drug had fine compatibility. The drug content in the fibers was found to be a little lower than that in the spinning liquid, 10.2％ of the drug was lost during the spinning processes. In vitro dissolution tests indicated that composite medicated fibers had better release profiles than PAN medicated fibers, 84.2％ of the incorporated ibuprofen was linearly released out during a time periods of 15 days.
Medicated teztiles wet spinning composite fibers drug delivery systems polyacrylonitrile polyvinylpyrrolidone
Deng-Guang Yu Xia-Xia Shen Li-Min Zhu C.Branford-White S.W.Annie Bligh Y.C.Yang
College of Chemistry,Chemical Engineering and Biotechnology Donghua University Shanghai,China Institute for Health Research and Policy London Metropolitan University London,UK
国际会议
北京
英文
1-4
2009-06-11（万方平台首次上网日期，不代表论文的发表时间）